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Active-Italia: The Potential Of Resveratrol In Cardiovascular Disease Treatment

The Potential Of Resveratrol In Cardiovascular Disease Treatment

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Cardiovascular diseases (CVDs) are considered to be the most common cause of the death in the global population and account for much treatment expenditures. The cardiovascular protection of resveratrol are associated with multiple molecular targets and which can lead to the development of novel therapeutic strategies for atherosclerosis, ischemia/reperfusion, metabolic syndrome, and heart failure, so on…

Hypertension

Hypertension is a chronic medical condition that is showed by sustained arterial blood pressure elevation.

Several investigators have demonstrated that resveratrol can lower BP in experimental animal models of hypertension with the molecular target of sirtuins and SIRT1.

With regard to its endothelium-dependent effects, resveratrol supplementation has been shown to improve flow-mediated vasodilation, a surrogate for endothelial function, in several animal models (Pearson et al., 2008; Rush, Quadrilatero, Levy, & Ford, 2007; Soylemez, Sepici, & Akar, 2009; Toklu et al., 2010).

Resveratrol increases the bioavailability of nitric oxide (NO) by increasing endothelial nitric oxide synthase (eNOS) expression to show the vasodilatory effects (Leikert et al., 2002; Wallerath et al., 2002).

Three isoforms of NO synthase (NOS), eNOS, neuronal NOS (nNOS), and inducible NOS (iNOS) could mediated level of NO (Calvert & Lefer, 2009).

eNOS plays important role in cardiovascular physiology because it regulates vascular tone via the release of NO in the vascular endothelium (Calvert & Lefer, 2009).

It has been showed that resveratrol involves the effects of resveratrol on silent information regulator 1 (SIRT1), AMP-activated protein kinase (AMPK), and reactive oxygen species (ROS) to increasing the NO bioavailability.

SIRT1 is a class III histone deacetylase which stimulates the NO production by deacetylating eNOS at lysine residues (Arunachalam, Yao, Sundar, Caito, & Rahman, 2010).

Resveratrol activates SIRT1 then mediates both activity and expression of eNOS (Csiszar et al., 2009).

It has been shown that resveratrol activates AMPK to stimulate NO production (Dolinsky et al., 2013).AMPK, a major regulator of energy metabolism (Nagendran, Waller, & Dyck, 2013), also regulates NO bioavailability via eNOS.

AMPK phosphorylatea and activatea eNOS on serine 1177, resulting in a subsequent increase in NO production (Z.-P. Chen et al., 1999). In addition to the involvement of SIRT1 and AMPK in mediating the endothelium-dependent vasodilatory effects, resveratrol has been shown to enhance NOS activity by increasing tetrahydrobiopterin (BH4) levels, a cofactor necessary for proper function of NOS (Carrizzo et al., 2013).

Source of the Article

Bui Thanh Tung VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam

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