Oleocanthal is a naturally occurring secoiridoid from olive oil, which was shown to exhibit potent anti-inflammatory, anticancer, and neuroprotective activities. The anti-inflammatory activity of oleocanthal is due to its dose dependent inhibition of cyclooxygenase (COX-1, COX-2) enzymes in the prostaglandin biosynthesis (inflammatory) in the same pathway as Ibuprofen. Anti-leishmanial activity was recently attributed to Oleocanthal when added in vitro and in vivo, in experimental models of Leishmania infection.
Oleacein is the main responsible of the positive effects of olive oil on cardiovascular system. Oleacein results, also, to be an inhibitor of MTOR pathway, an important methabolism and cellular growth regulation mechanism. Oleacein in vitro tests showed antinflammatory, antiatherosclerotic and antihypertensive properties, this last one by the inihibition of the angiotensin conversion enzyme, moreover, Oleacein is an inhibitor of the mammalian/mechanistic target of rapamycin (mTOR), an important metabolism and cellular growth regulation mechanism related to lifespan and aging.
The TPF improves redox status by increasing levels of GSH, one of the most important antioxidant molecules, in both endothelial cells and myoblasts.
CAS Numbers: Oleocanthal 289030-99-5; Oleacein 149183-75-5
Molecular Weight: OLEA 304.34 OLEO 320.34
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