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Active-Italia: Phytochemistry: ibuprofen-like activity in extra-virgin olive oil

Phytochemistry: ibuprofen-like activity in extra-virgin olive oil

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Enzymes in an inflammation pathway are inhibited by oleocanthal, a component of olive oil.

Newly pressed extra-virgin olive oil contains oleocanthal a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen.

We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen.

Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.

Source of the Article

Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PA. Nature. 2005 Sep 1;437(7055):45-6. doi: 10.1038/437045a. PMID: 16136122.

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The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds
Virgin olive oil (VOO) is credited as being one of the many healthful components associated with the Mediterranean diet. Mediterranean populations. . .
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