Active-Italia: Literature

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The articles we have listed below were compiled and written by experts and practitioners within the field as well as based on professional research of the industry and related trends, opportunities, and projections. If you have a suggestion about a future article or comment about a current one, please contact us.

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Skin care & disorders
Leishmaniasis
Bioavailability
anti-inflammatory
cancer
cardio vascular diseases
neurodegenerative diseases
rheumatic diseases
TPF
rheumatoid arthritis
Allergic diseases
DERMATITIS AND PSORIASIS

The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells

Mol. Sci. 2020, 21, 8074. https://doi.org/10.3390/ijms21218074

Skin Protective Nutraceuticals: The Current Evidence in Brief

Mol. Sci. 2020, 21, 8074. https://doi.org/10.3390/ijms21218074

Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Mol. Sci. 2020, 21, 8074. https://doi.org/10.3390/ijms21218074

The Impact of Olive Oil Compounds on the Metabolic Reprogramming of Cutaneous Melanoma Cell Models

Brito C, Tomás A, Silva S, Bronze MR, Serra AT, Pojo M. Molecules. 2021 Jan 8;26(2):289. doi: 10.3390/molecules26020289. PMID: 33430068; PMCID: PMC7827395.

Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability

Mol. Sci. 2020, 21, 8074. https://doi.org/10.3390/ijms21218074

Hydroxytyrosyl Oleate: Improved Extraction Procedure from Olive Oil and By-Products, and In Vitro Antioxidant and Skin Regenerative Properties

Mol. Sci. 2020, 21, 8074. https://doi.org/10.3390/ijms21218074

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

Działo M, Mierziak J, Korzun U, Preisner M, Szopa J, Kulma A. Int J Mol Sci. 2016 Feb 18;17(2):160. doi: 10.3390/ijms17020160. PMID: 26901191; PMCID: PMC4783894.

Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer

Polini B, Digiacomo M, Carpi S, Bertini S, Gado F, Saccomanni G, Macchia M, Nieri P, Manera C, Fogli S. Toxicol In Vitro. 2018 Oct;52:243-250. doi: 10.1016/j.tiv.2018.06.021.

Could Polyphenols Really Be a Good Radioprotective Strategy?

Faramarzi, S.; Piccolella, S.; Manti, L.; Pacifico, S. Could Polyphenols Really Be a Good Radioprotective Strategy? Molecules 2021, 26, 4969

Investigations of Olive Oil Industry By-Products Extracts with Potential Skin Benefits in Topical Formulations

Nunes, A.; Gonçalves, L.; Marto, J.; Martins, A.M.; Silva, A.N.; Pinto, P.; Martins, M.; Fraga, C.; Ribeiro, H.M. Pharmaceutics 2021, 13, 465

Total Phenolic Fraction (TPF) from Extra Virgin Olive Oil: Induction of apoptotic-like cell death in Leishmania spp. promastigotes and in vivo potential of therapeutic immunomodulation

Karampetsou K, Koutsoni OS, Gogou G, Angelis A, Skaltsounis LA, Dotsika E.

Evaluation of total phenolic fraction derived from extra virgin olive oil for its antileishmanial activity

Koutsoni OS, Karampetsou K, Kyriazis ID, Stathopoulos P, Aligiannis N, Halabalaki M, Skaltsounis LA, Dotsika E. Phytomedicine. 2018 Aug 1;47:143-150. doi: 10.1016/j.phymed.2018.04.030. Epub 2018 May 10. PMID: 30166099.

Oleocanthal as a Promising Natural Therapeutic Agent: the Experimental Leishmaniasis Paradigm

Dotsika, Eleni & Karampetsou, Kalliopi & Koutsoni, Olga & Angelis, Apostolis & Halabalaki, Maria & SKALTSOUNIS, LEANDROS‐ALEXIOS. (2019). The FASEB Journal. 33. 10.1096/fasebj.2019.33.1_supplement.lb34.

Tissue Distribution of Oleocanthal and Its Metabolites after Oral Ingestion in Rats

López-Yerena, A.; Vallverdú-Queralt, A.; Jáuregui, O.; Garcia-Sala, X.; Lamuela-Raventós, R.M.; Escribano-Ferrer, E. Antioxidants 2021, 10, 688.

Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats

López-Yerena A, Vallverdú-Queralt A, Mols R, Augustijns P, Lamuela-Raventós RM, Escribano-Ferrer E. Pharmaceutics. 2020 Feb 5;12(2):134. doi: 10.3390/pharmaceutics12020134. Erratum in: Pharmaceutics. 2020 Dec 17;12(12): PMID: 32033424; PMCID: PMC7076358.

Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties

Bucciantini, M.; Leri, M.; Nardiello, P.; Casamenti, F.; Stefani, M. Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants 2021, 10, 1044.

Potential of Olive Oil Mill Wastewater as a Source of Polyphenols for the Treatment of Skin Disorders: A Review

Bucciantini, M.; Leri, M.; Nardiello, P.; Casamenti, F.; Stefani, M. Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants 2021, 10, 1044.

Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: an ex vivo and in vivo study using an NC/Nga mouse model

Bucciantini, M.; Leri, M.; Nardiello, P.; Casamenti, F.; Stefani, M. Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants 2021, 10, 1044.

Identification of Tyrosyl Oleate as a Novel Olive Oil Lipophenol with Proliferative and Antioxidant Properties in Human Keratinocytes

Benincasa, C.; La Torre, C.; Fazio, A.; Perri, E.; Caroleo, M.C.; Plastina, P.; Cione, E. Antioxidants 2021, 10, 1051.

Olive-Oil-Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF-κB Pathway

Aparicio-Soto M, Redhu D, Sánchez-Hidalgo M, Fernández-Bolaños JG, Alarcón-de-la-Lastra C, Worm M, Babina M. Mol Nutr Food Res. 2019 Nov;63(21):e1900019. doi: 10.1002/mnfr.201900019. Epub 2019 Aug 19. PMID: 31393642.

Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies

Emma, M.R.; Augello, G.; Di Stefano, V.; Azzolina, A.; Giannitrapani, L.; Montalto, G.; Cervello, M.; Cusimano, A. Int. J. Mol. Sci. 2021, 22, 1234.

Anticancer molecular mechanisms of oleocanthal

El Haouari M, Quintero JE, Rosado JA. Phytother Res. 2020 Nov;34(11):2820-2834. doi: 10.1002/ptr.6722.

A Polyphenol-Rich Extract of Olive Mill Wastewater Enhances Cancer Chemotherapy Effects, While Mitigating Cardiac Toxicity

Emma, M.R.; Augello, G.; Di Stefano, V.; Azzolina, A.; Giannitrapani, L.; Montalto, G.; Cervello, M.; Cusimano, A. Int. J. Mol. Sci. 2021, 22, 1234.

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

Melguizo-Rodríguez L, de Luna-Bertos E, Ramos-Torrecillas J, Illescas-Montesa R, Costela-Ruiz VJ, García-Martínez O. 2021 Jul 15;10(7):1642. doi: 10.3390/foods10071642. PMID: 34359512; PMCID: PMC8307686.

Cardioprotective Activity of Selected Polyphenols Based on Epithelial and Aortic Cell Lines.

Otręba M, Kośmider L, Stojko J, Rzepecka-Stojko A. Molecules. 2020;25(22):5343. Published 2020 Nov 16. doi:10.3390/molecules25225343

Hydroxytyrosol and its complex forms (secoiridoids) modulate aorta and heart proteome in healthy rats: Potential cardio-protective effects

Catalán Ú, Rubió L, López de Las Hazas MC, Herrero P, Nadal P, Canela N, Pedret A, Motilva MJ, Solà R. Mol Nutr Food Res. 2016 Oct;60(10):2114-2129. doi: 10.1002/mnfr.201600052.

Antioxidant and antiplatelet activity by polyphenol-rich nutrients: focus on extra virgin olive oil and cocoa

Loffredo L, Perri L, Nocella C, Violi F. Br J Clin Pharmacol. 2017 Jan;83(1):96-102. doi: 10.1111/bcp.12923.

Natural Molecules for Healthy Lifestyles: Oleocanthal from Extra Virgin Olive Oil

Francisco V, Ruiz-Fernández C, Lahera V, Lago F, Pino J, Skaltsounis L, González-Gay MA, Mobasheri A, Gómez R, Scotece M, Gualillo O. J Agric Food Chem. 2019 Apr 10;67(14):3845-3853. doi: 10.1021/acs.jafc.8b06723. Epub 2019 Mar 27. PMID: 30875206.

Polyphenolic extract from extra virgin olive oil inhibits the inflammatory response in IL-1β-activated synovial fibroblasts

Rosillo, M., Alarcón-de-la-Lastra, C., Castejón, M., Montoya, T., Cejudo-Guillén, M., & Sánchez-Hidalgo, M. (2019). British Journal of Nutrition, 121(1), 55-62. doi:10.1017/S0007114518002829

The Antioxidant Resveratrol Protects against Chondrocyte Apoptosis by Regulating the COX-2/NF- κ B Pathway in Created Temporomandibular Osteoarthritis

Li W, Hu S, Chen X, Shi J. Biomed Res Int. 2021 Jul 9;2021:9978651. doi: 10.1155/2021/9978651. PMID: 34307684; PMCID: PMC8285176.

Oleocanthal Inhibits Catabolic and Inflammatory Mediators in LPS-Activated Human Primary Osteoarthritis (OA) Chondrocytes Through MAPKs/NF-κB Pathways

Scotece M, Conde J, Abella V, López V, Francisco V, Ruiz C, Campos V, Lago F, Gomez R, Pino J, Gualillo O. Cell Physiol Biochem. 2018;49(6):2414-2426. doi: 10.1159/000493840. Epub 2018 Sep 27. PMID: 30261513.

Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases

Rodríguez-Morató J, Xicota L, Fitó M, Farré M, Dierssen M, de la Torre R. Molecules. 2015 Mar 13;20(3):4655-80. doi: 10.3390/molecules20034655. PMID: 25781069; PMCID: PMC6272603.

Antioxidant effects of an olive oil total polyphenolic fraction from a Greek Olea europaea variety in different cell cultures

Paraskevi Kouka, Georgia-Anna Chatzieffraimidi, Grigorios Raftis, Dimitrios Stagos, Apostolis Angelis, Panagiotis Stathopoulos, Nikos Xynos, Alexios-Leandros Skaltsounis, Aristides M. Tsatsakis, Demetrios Kouretas.

Available online 8 May 2018

Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol

Hecht JT, Veerisetty AC, Wu J, Coustry F, Hossain MG, Chiu F, Gannon FH, Posey KL. Am J Pathol. 2021 Sep;191(9):1624-1637. doi: 10.1016/j.ajpath.2021.05.016. Epub 2021 Jun 8. PMID: 34116024; PMCID: PMC8420863.

Polyphenols and their Mechanism of Action in Allergic Immune ResponseImmune Response

POLYPHENOLS AND THEIR MECHANISM OF ACTION IN ALLERGIC IMMUNE RESPONSE

Olives and Olive Oil in Health and Disease Prevention

Victor Preedy, Ronald Watson

Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation

Cellat M, Kuzu M, İşler CT, Etyemez M, Dikmen N, Uyar A, Gökçek İ, Türk E, Güvenç M.

Dermatite o eczema atopico avambraccio

Tyrosol Suppresses Allergic Inflammation by Inhibiting the Activation of Phosphoinositide 3-Kinase in Mast Cells

Je IG, Kim DS, Kim SW, Lee S, Lee HS, Park EK, Khang D, Kim SH

prevenzione delle allergie

Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects

Bonura A, Vlah S, Longo A, Bulati M, Melis MR, Cibella F, Colombo P.

Influence of polyphenols on allergic immune reactions: mechanisms of action

Thea Magrone and Emilio Jirillo

photodynamic therapy

Topical treatment with oleocanthal extract in reducing inflammatory reactions after photodynamic therapy: a prospective quasi-experimental pilot study

Segura Palacios JM, Blázquez Sánchez N, Rivas Ruiz F, Aguilar Bernier M, Ramírez López B, Sánchez MEF, de Troya Martín M.

The Role of Polyphenols in Rosacea Treatment: A Systematic Review

Saric S, Clark AK, Sivamani RK, Lio PA, Lev-Tov HA

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