From Extra Virgin Olive Oil,
Oleocanthal, Oleacein and CMP

Our expertise lies in extracting polyphenols from extra virgin olive oil (EVOO) for dietary supplements and pharmaceutical applications, ensuring strict quality control from the cultivation of olive trees to the production of CMP (Complex Mixture of Polyphenols), which includes oleacein, oleocanthal, tyrosol, and hydroxytyrosol. Through a meticulous process that oversees every stage of production, we aim to create products that not only enrich the diet but significantly improve health and overall well-being, leveraging the natural power of polyphenols. Our mission is clear: to provide advanced health solutions rich in polyphenols, promoting lasting and meaningful well-being. 

CMP (Complex Mixture of Polyphenols)

Phenolic derivatives are one of the most important compounds that were found in secondary metabolites in plants. They can be utilized in various fields such as antioxidant, antimicrobial, anti-inflammatory, antitumor, antiviral, analgesic and antipyretic. The CMP (Complex Mixture of Polyphenols) or total phenolic fraction (TPF) protect cells from oxidative stress due to the strong antioxidant activity of its polyphenols more than each separate compound. 

A Constantly Evolving Research in the Extraction of Phenolic Compounds

Oleocanthal, a Phenolic Derived from Virgin Olive Oil

We combine exclusive processes of extraction, purification and refining, which allow us to obtain extracts with very high concentrations of phenolic compounds.

GREEN TECHNOLOGY for the Isolation and Purification of Oleacein and Oleocanthal

Our method allows the total recovery of CMP from EVOO, in an eco-sustainable way.

Research & Technological Development for a completely “green chemistry”

We work to develop and implement green and sustainable chemistry in new products and processes.

Our strengths

only natural ingredients

We are committed to developing natural and innovative ingredients, providing safe and high quality products and contributing to human health and well-being.


Active Italia uses raw materials of its own production or procures from partners who have a production cycle according to criteria of environmental, social and economic sustainability.

total quality

We believe that the high quality natural ingredients come from the best raw materials and the best quality control in the production process.

The Power
of Nature

the natural pharmaceutical industries.

To date, more than 390,000 plant species are documented worldwide, and botanists are still discovering around 2,000 each year.

Thanks to the progress made in extraction methods, new medicinal properties have been discovered, and the set of active molecules in the plant are being better and better preserved.

Get Insights on Developments in Biomedical Research

There’s an ocean of publications in biomedical research. We want to help you navigate through them, by bringing you relevant information suited to your professional needs and interests.

Active Italia
Oleocanthal , 289030-99-5 , Oleocanthal, Phenolic, Effects, Compounds, Treatment, Cancer, Activity, Anti-Inflammatory, Oleacein, Compound, Study, Potential, Health, Effect, Human, Diseases, Studies, Properties, Results, Expression, Inflammation, Viability, Disease, Protein, Phenolic Compounds, Concentration, Cell Viability, Inflammatory, Levels, Biological, Natural, Cell Lines, Ibuprofen, Anticancer, Inhibition, Significant, Activities, Methods, Concentrations, Data, Method, Oleuropein, Analysis, Extraction, Vitro, Phenolic Compound, Apoptosis, Inhibitor, Cox-2, Alzheimer, Breast, Polyphenols, Extract, Primary, Mechanism, Mechanisms, Secoiridoids, Induced, Molecular, Phenols, Receptor, Antioxidant, Assay, Activation, Potent, Oxidative, Growth, Pharmacological, Samples, Hydroxytyrosol, Carcinoma, Neurodegenerative, Factors, Development, Synthesis, Neuroprotective, Group, Chondrocytes, Aglycone, Tumor, Profile, Control, Inhibits, Cancer Cells, Cancer Cell, Breast Cancer, Pathways, Proteins, Effective, Biological Activity, Formation, Liquid, Mitochondrial, Research, Significantly, Mice, Derivatives, Agent, Macrophages, Dietary, Proliferation, Hepatocellular, Experiments, Inhibited, Chromatography, Hepatocellular Carcinoma, Isolated, Bioactive, Anti-Inflammatory Activity, Non-Steroidal Anti-Inflammatory, Neurodegenerative Diseases, Alzheimer ‘S Disease, Pharmacological Properties, Oral Cavity, Gene Expression, Cancer Cell Lines, J774 Macrophages, Cell Line, Anticancer Effects, Cell Growth, Anti-Inflammatory Properties, Dna Damage, Estrogen Receptors, Anti-Inflammatory Drug, Human Health, Biological Activities, Chronic Diseases, Reactive Oxygen, Mitochondrial Membrane, Human Hepatocytes, Liquid Chromatography, Lysosomal Membrane, Nadph Oxidase, Pro-Inflammatory Factors, Health Effects, Control Cells, Reactive Oxygen Species, Breast Cancer Cell, Oxygen Species, Natural Products, Colon Cancer, Cell Death, Receptor α, Hep3b Cells, Gene Activity, Cell Proliferation, Anti-Inflammatory Activities, Apoptotic Cells, Bioactive Compounds, Protein Synthesis, Murine Macrophages, High-Performance Liquid, Human Diseases, Membrane Permeabilization, Flow Cytometry, Non-Steroidal Anti-Inflammatory Drug, Anti-Inflammatory Compound, Natural Compound, Nonsteroidal Anti-Inflammatory, Neuroprotective Properties, Parp Cleavage, Inflammatory Response, Anticancer Activities, Potential Anticancer, Hepatic Steatosis, Induced Apoptosis, Inflammatory Diseases, Molecular Mechanisms, Bioactive Compound, Mass Spectrometry, Neuroprotective Effects, High-Performance Liquid Chromatography, Anticancer Activity, Untreated Cells, Preclinical Studies, U2os Cells, Culture Supernatant, Protein Expression, Growth Inhibition, Mitochondrial Depolarization, Mouse Model, Degenerative Diseases, Estrogen Receptor, Low Levels, Sw480 Cells, Lysine Residues, Vivo Studies, Luciferase Activity, Fatty Acid, Estrogenic Properties, Breast Cancer Cells, Cytometry Analysis, Base Formation, Hepg2 Cells, Cell Growth Inhibition, Cancer Cell Viability, Anti-Inflammatory Drugs, Membrane Potential, Estrogen Receptor α, Flow Cytometry Analysis, Cardiovascular Disease, Inhibitory Effect, Colorectal Cancer, Biological Effects, Mitochondrial Membrane Potential, Antioxidant Activity, Neurodegenerative Disease, Viability Assays, Liver Cancer, Superoxide Anions, Cell Cycle, Melanoma Cells, Mechanistic Studies, Tumor Growth, Antiinflammatory Properties, Carcinoma Cells, Anticancer Drug, Mass Spectrometric, Gene Products, Calibration Curve, Tumor Necrosis, Receptor Genes, Colon Cancer Cells, Food Additives, Phenolic Composition, Volatile Compounds, Inflammatory Disease, Human Hepatocellular Carcinoma, Potential Anticancer Effects, Cell Viability Assays, Tumor Cells, Potent Anti-Inflammatory Activity, Chronic Inflammatory, Carcinoma Cell, Human Hepatocellular, Primary Chondrocytes, Colorectal Carcinoma, Aldehyde Groups, Protein Levels, Induced Damage, Dose Range, Synaptic Proteins, Il-6 Protein, Potential Health, Biological Assays, Epidemiological Studies, Cancer Therapy, Sample Extraction, Cox-2 Inhibitor, Acetylcholine Esterase, Anti-Proliferative Effects, Fluorescent Probe, Inflammatory Reaction, Transport Proteins, Liquid–Liquid Extraction, Tumor Cell, Nf-κb Pathway, Metabolic Parameters, Abdominal Fat, Malignant Melanoma, Care Products, High Levels, Low Concentrations, Antitumor Effects, Chemotherapeutic Potential, Nutraceutical Properties, Phenolic Profiles, Phenolic Profile, Toxic Effect, Potent Anticancer Activity, Non-Melanoma Skin, Kinase Domain, Neuroendocrine Tumors, Human Liver, Clinical Trials, Inhibitory Activity, Potent Anticancer, Cellular Toxicity, Phenolic Extracts, Neural Cells, Skin Cancer, Liver Cancer Cell, Murine Peritoneal, Anti-Inflammatory Agent, Cancer Cell Death, Carcinoma Cell Lines, Nonsteroidal Anti-Inflammatory Drug, Hepatocellular Carcinoma Cell, Aβ Oligomers, Fatty Acids, Chromatin Condensation, Mammalian Cells, Carboxylic Ester, Amino Acid, Lead Compound, Gene Product, Primary Health, Peritoneal Macrophages, Solvent System, Dietary Supplement, Cytotoxic Activity, Anti-Inflammatory Effect, Heat Treatment, Nervous System, Microtubule-Associated Protein, Cytotoxic Effect, Active Substances, Inhibitory Potential, Analytical Method, Hplc Analysis, Acid Residues, Lps-Stimulated Macrophages, Magnetic Resonance, Food Chemistry, Antioxidant Activities, Pharmacological Activity, Function Studies, Human Colorectal, Polyphenol Extract, Inflammatory Cytokines, Factor α, Intestinal Absorption, Plasma Samples, Membrane Depolarization, Necrosis Factor, Oxidative Stability, Systemic Chemotherapy, Lipoprotein Receptor, Surface Plasmon, Intestinal Metabolism, Metabolic Syndrome, Alanine Transaminase, Natural Compounds, C-Met Inhibitors, Cutaneous Inflammation, Receptor β, Neuroprotective Effect, Functional Food, Plasmon Resonance, Potent Inhibitor, Endothelial Cells, Necrosis Factor α, Human Melanoma, Enzymatic Activity, Cox-2 Expression, Metastatic Breast, Plc/Prf/5 Cells, Brain Endothelial, Mammalian Target, Osteosarcoma Cells, Aβ Levels, Receptor Tyrosine, Murine Peritoneal Macrophages, Activation Mechanism, Neuroprotective Activities, Time-Dependent Inhibition, Ethyl Acetate, Acid Profile, Mice Brain, Growth Factor, Animal Disease, Clinical Studies, Animal Model, Mitochondrial Membrane Depolarization, Pro-Inflammatory Cytokines, Chronic Inflammatory Disease, Microtubule Assembly, Inhibits The Growth, Malignant Tumor, Primary Cell, Europaea L., Epidermal Growth, Covalent Modification, Human Plasma, Biological Properties, Extraction Process, Oral Absorption, Cox-1 Inhibitor, Cox-2 Protein, Brain Endothelial Cells, Non-Steroidal Anti-Inflammatory Drugs, Hepatocellular Carcinoma Cells, Surface Plasmon Resonance, Nuclear Magnetic Resonance, Fatty Acid Profile, Human Melanoma Cells, Tumor Necrosis Factor, Amino Acid Residues, Vitro Studies, Solvent Mixture, Eutectic Solvents, Wild-Type Mice, P-Gp Expression, P-Gp Substrate, Bone Lesions, Anti Tumor, Tumor Activity, Myeloma Cell, Glycolytic Enzyme, Significant Health, Cells Proliferation, Vitro Activity, Metabolic Profile, Annexin V/Propidium, Mitochondrial Superoxide, Low Density, Density Lipoprotein, Natural Molecules, Brain Samples, Drug Targets, Inhibits Cell, Human Hepatocyte, Anticancer Drugs, Fibrillary Acidic, Oxidase Inhibitor, Mitochondrial Function, Cardiovascular Diseases, Molecular Docking, Anti-Cancer Agents, Primary Human, Disease Development, Adenosine Triphosphate, Risk Factors, Phenolic Antioxidants, Molecular Mechanism, Osteolytic Bone, Inflammatory Protein, Macrophage Inflammatory, Hematological Malignancies, Cell Malignancy, Plasma Cell, Significant Concentrations, Expression Levels, Tyrosine Kinases, Apoptotic Cell, Isolated Cells, Oxygen Metabolites, Cell Carcinoma, Antitumor Activity, Transduction Pathways, Signal Transduction, Dermal Fibroblasts, Micromolar Range, Significant Inhibition, Bcl-2 Expression, Cardiovascular Risk, Potential Neuroprotective, Clinical Effects, Steroidal Anti-Inflammatory, Wst-1 Assay, Bitter Taste, Analytical Methods, Antiproliferative Activity, Disease Process, Human Malignant, Human Breast, C-Met Inhibitor, Squamous Cell, Membrane Stability, Anticancer Agents, Cancer Research, Drug Target, Control Mice, Red Fluorescence, Response Surface, Surface Methodology, Pharmacological Effects, Neurodegenerative Disorders, Mass Spectrometer, Xenograft Model, Vanillic Acid, Human Cancer, Esterase Inhibitor, Inhibits Proliferation, Anti-Inflammatory Cytokines, Body Mass, Mass Index, Subcutaneous Fat, Vitro Study, Visceral Fat, Rat Plasma, Oil Extraction, Protein Phosphorylation, Oxidase Enzyme, Cancer Cell Line, Biphasic System, Organic Phase, Biphasic Solvent, Antiinflammatory Drug, Body Mass Index, Chemopreventive Properties, Anticancer Properties, Hydrolysis Products, Countercurrent Chromatography, Isolation Method, High Concentration, Concentration Levels, Amyloid Diseases, Phenolic Acids, Spheroid Formation, Proteomic Analysis, Signal Transduction Pathways, Tumor Necrosis Factor-α, Inhibits Cell Viability, Fibrillary Acidic Protein, Bioactive Natural Products, Terminal Deoxynucleotidyl, Calibration Curves, Uv Detection, Myeloma Cell Line, Low Micromolar Range, Cell Transplant, Sh-Sy5y Cells, Computational Studies, Ca2+ Homeostasis, Mitochondrial Functions, Antioxidant Enzymes, Squamous Cell Carcinoma, Nonsteroidal Antiinflammatory Drug, Anti Tumor Activity, Reversed-Phase Hplc, Macrophage Inflammatory Protein, Epidermal Growth Factor, Malignant Melanoma Cells, Human Malignant Melanoma, Potential Anticancer Activity, Adipose Tissue, Geometric Isomers, Drug Activity, Solvent Extract, Metastatic Breast Cancer, Inhibition Studies, Nadph Oxidase Inhibitor, Natural Agent, Photodynamic Therapy, Necrotic Cells, Apoptotic Effects, Caspase Activity, Ht29 Cells, Colon Carcinoma, 1,3-Dipolar Cycloaddition, Chemical Proteomics, Intestinal Inflammation, Natural Inhibitor, Glucose Transporter, Transgenic Mice, Cytotoxic Effects, Antioxidant Enzyme, Vivo Model, Parenchymal Cells, Experimental Animal, Pyruvate Kinase, Hsp90 Inhibitor, Breast Cancer Treatment, Target Compounds, Inhibitory Activities, Inhibitor Rotenone, Cancer Model, Nonsteroidal Antiinflammatory, Chemical Synthesis, Low Density Lipoprotein, Human Cancer Cell, Primary Human Hepatocytes, Cancer Cell Growth, Human Liver Cancer, Response Surface Methodology, Receptor Tyrosine Kinases, Plant Natural Products, Apoptotic Cell Death, Treatment Response, Organic Solvents, Acidic Protein, Potential Agents, Pathogen Infection, Cutaneous Squamous Cell, Cancer Treatment, Control Group, Anti-Cancer Activity, Effective Treatment, Signal Transducer, Yellow Color, Platelet Inhibition, Genomic Dna, Dna Sequences, Platelet Function, Genetic Diversity, Growth Factor-1, Concentration Values, Low-Density Lipoproteins, Anti-Oxidant Properties, High Concentrations, Enzyme Catalyzes, Leaf Extract, Apoptotic Pathway, C-Met Kinase, Experimental Studies, Synergistic Effects, Active Site, Isotope Dilution, Protein Structures, Xanthine Oxidase, Biochemical Methods, Cycle Analysis, Cancer Line, Lead Molecule, Molecular Modelling, Cancer Diseases, Binding Sites, Lead Compounds, Low Temperature, Specific Enzyme, Active Sites, Antioxidant Compounds, Chemical Composition, Acid Composition, Cardiovascular Health, Multivariate Analysis, Oxidation Product, Cancer Tissues, Formic Acid, Enzymatic Assay, Antioxidant Properties, Intracellular Targets, Cardiovascular Disorders, Oxidase Activity, Fluorescence Microscopy, Apoptosis Detection, Flow Cytometer, Intestinal Epithelium, Dimethyl Acetal, Methanolic Extracts, Cell Culture, Receptor Proteins, Inhibit Growth, Primary Hepatocytes, Human Hepatocarcinoma, Human Cell, Interaction Studies, Huh-7 Cells, Phenolic Alcohols, Solid Phase, Jc-1 Staining, Molecular Signaling, Human Tissues, Superoxide Anion, Luminescent Cell, Nucleic Acid, Molecular Probes, Antitumoral Activity, Potential Anti-Inflammatory, Toxic Effects, Healthy Cells, Target Proteins, Serine/Threonine Kinase, Ligand Interaction, Hepatic Damage, Receptor Ligand, Liver Transplantation, Cancer Therapies, Polyphenol Oxidase, Rat Model, Myeloma Cells, Biomimetic Synthesis, Gastrointestinal Cancer, Functional Activity, Pharmacokinetic Properties, Human Adenocarcinoma, Adenocarcinoma Cells, Triterpene Acid, Nmr Data, Membrane Permeable, Triterpenic Acids, Amp-Activated Protein, Receptor Agonist, Protein Kinase, Molecular Modeling, Viral Hepatitis, Study Group, Cox-2 Inhibitors, Cyclooxygenase-2 Inhibitors, Seed Oil, Caspase Activation, Molecular Targets, Vivo Activities, Quadrupole Mass, Intracellular Levels, Chemical Parameters, Cyclopentane Ring, Antiproliferative Effects, Microbial Infections, Immunomodulatory Properties, Trpv1 Agonists, Prostate Tumor, Cancer Xenograft, Significant Activity, High Selectivity, Solid Tumors, Infected Plants, Molecular Structure, Thermal Stability, Drug Resistance, Dilution Assay, Cardiovascular System, Cell Lysates, Receptor Antagonist, Potent Chemopreventive, Cell-Based Assays, Radical Absorbance, Phenolic Substances, Inhibitory Concentration, Antiproliferative Activities, Small-Molecule Inhibitors, Oncogenic Signaling, Dna Fragmentation, Active Substance, Pharmaceutical Compositions, Hplc Profiles, Chromatographic Methods, Human Keratinocytes, Gel Electrophoresis, Polymerase Chain, Multivariate Analyses, Membrane Bound, Ligand Binding, Anticarcinogenic Activity, Low Dosage, Anti-Inflammatory Effects, Dimethyl Sulfoxide, Potent Antioxidant, Fluorescence Probe, Human Hepatic, Hepatic Cancer, Mek/Erk Pathway, Inhibits Cancer, Induce Cancer, Malignant Cells, Prostate Cancers, Antitumor Activities, Prostaglandin E2, Proteasome Inhibitor, Inhibitor Mg132, Synergistic Antiproliferative, Proapoptotic Effects, Colorectal Adenomas, Cyclooxygenase-2 Expression, Inhibits Growth, Pharmacological Potential, Isolated Human, Pharmacological Activities, Mass Spectrometric Detection, Prostate Cancer Cell, Human Breast Cancer, Biphasic Solvent System, Type 2 Diabetes, Terminal Deoxynucleotidyl Transferase, Cell Cycle Analysis, Deoxynucleotidyl Transferase, Amyloid β Peptide, Tumor Cell Lines, Colorectal Cancer Cells, Quadrupole Mass Spectrometer, Maximal Inhibitory Concentration, Oxygen Radical Absorbance, Fatty Acid Composition, Cell Carcinoma Cells, Agric Food Chem, Amyloid β, Crop Yield, Cancer Xenograft Model, Alzheimer ‘S Diseases, Hepatocyte Growth Factor, Receptor Tyrosine Kinase, Molecular Modeling Studies, Human Colorectal Cancer, Inhibits Cancer Cell, Amp-Activated Protein Kinase, Mitochondrial Respiratory Chain, Proteasome Inhibitor Mg132, Reversed-Phase High-Performance Liquid, Cell Line Hepg2, Human Colorectal Carcinoma, Fetal Bovine Serum, Xanthine Oxidase Activity, Reactive Oxygen Metabolites, Human Cell Line, Colon Carcinoma Cell, Cyclooxygenase 2 Inhibitor, Tumor Cell Growth, Breast Cancer Model, Fungal Disease, Verticillium Dahliae, Analytical Data, Oil Phase, Extraction Methods, Chromatography Techniques, Mg/Kg Dose, Mammary Epithelial, Skbr-3 Cells, Primary Tumor, Natural Ligands, Synergic Effect, Functional Impairment, P53 Mutant, Orthotopic Xenograft, Xenograft Mice, Acyl Groups, Tumour Growth, Glucosamine Sulfate, Blood Lipids, Fatty Alcohols, α-Amylase Inhibition, Potential Mechanism, Complex Mixture, Health-Promoting Effects, Extraction Techniques, Low Yields, Method Validation, Spectrometric Detection, Enzymatic Hydrolysis, Lipid Metabolism, H2o2-Induced Oxidative, Apoptosis Inducer, Hydroxyl Group, Hydrogen Atom, Dietary Polyphenols, Cancer Development, Heat-Shock Proteins, Protein Targets, Chronic Inflammation, Ic50 Values, Age-Related Diseases, Liver Cancer Cells, Colorectal Cancer Cell, Microtiter Plates, Antineoplastic Agent, Dose-Dependent Inhibition, Arachidonic Acid, Ethyl Ester, Natural Product, E/Z Isomers, Pharmacological Studies, Plant Metabolite, Neuroprotective Agent, Drug Discov, Human Colon Carcinoma, Redox Signal, Neuroprotective Mechanism, Effective Method, Apoptotic Bodies, Control Values, Apoptosis Inhibition, Viable Cells, Respiratory Chain, Free-Radical Scavenging, Drug Molecule, Life Technologies, Bovine Serum, Inhibitor Concentrations, Clonogenic Assay, Crystal Violet, Activity Assays, Primary Antibodies, Anti-Oxidant Activity, Hepatocarcinoma Cell, Natural Antioxidants, Spectrum Disorders, Anti-Inflammatory Compounds, Enzyme Activities, Line Hepg2, Emission Wavelength, Fluorescence Microscope, Co2 Incubator, Vitro Antioxidant, Fetal Bovine, Specific Inhibitors, Sodium Azide, Light Microscopy, Microvessel Density, Prostate Cancer, Choline Chloride, Human Colon, Plant Polyphenols, Pro-Apoptotic Activity, Pro-Oxidant Activity, Cancer Chemoprevention, Biochem Pharmacol, Mitochondrial Ca2+, Tyrosine Phosphorylation, Hl60 Cells, Nadph Oxidases, Cellular Physiology, Mirna Expression, Inflammatory Reactions, Degenerative Disease, Colon Carcinoma Cells, Anti-Angiogenic Activity, Functional Properties, Cell Morphology, Tyrosine Kinase, Food Chem, Reversed-Phase High-Performance, Organic Acids, Inflammatory Pathways, Inflammatory Markers, Cell Carcinomas, Transitional Cell, Hepatocyte Growth, High-Affinity Receptor, Active Agent, Caspase Assay, Apoptotic Response, Sample Preparation, Cancer Drugs, Liver Disease, Pro-Apoptotic Effects, Specific Drugs, Anti-Cancer Effects,

Contact us.

We want to hear from you, understand your objectives, and discuss how we can build the perfect relationship for your next project.